Impact of ethnicity on platelet function and response to aspirin and clopidogrel

The purpose of this study is to evaluate the effectiveness of dual antiplatelet therapy with aspirin and clopidogrel in American Indians and to determine the incidence of CYP2C19 variant alleles in this understudied population. The original study design evaluates several underrepresented groups, however, due to limited funding; we have temporarily restricted our study population to Native Americans (50 healthy subjects and 50 subjects taking aspirin and clopidogrel) and Caucasians and will evaluate platelet function in the treated patients and genotyping of the CYP2C19 gene in all subjects.